Mapping aggregation-specific interactions in human disease

Newest publications

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  Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

  Katerina Konstantoulea, Meine Ramakers, Sarah C. Borrie, Dries T’Syen, Daan Moechars, Malgorzata A. Sliwinska, Brajabandhu Pradhan, Giulia Albertini, Nóra Baligács, Grigoria Tsaka, Bert Houben, Mark Fiers, Rodrigo Gallardo, Maarten Dewilde, Dietmar Rudolf Thal, Michael Willem, Jonas J. Neher, Bart De Strooper, Frederic Rousseau, Joost Schymkowitz

  Proc Natl Acad Sci US 2026 Mar 10

  PubMed
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  Conformation-specific monoclonal antibodies reveal early Tau structural intermediates in Alzheimer's disease

  Grigoria Tsaka, Aida Montserrat Pagès, Cristiano Brás De Sousa, Jeroen Lammertyn, Grzegorz Walkiewic, Luis Aragão Gomes, Maya Imbrechts, Sophie Tops, Rajasekhar Kolla, Kevin Muwonge, Rik Vandenberghe, Karen Vanhoorelbeke, Christine A F von Arnim, Nick Geukens, Frederic Rousseau, Joost Schymkowitz, Dragana Spasic, Dietmar Rudolf Thal, Debby Thomas, Joris Winderickx

  J Biol Chem . 2026 Feb 3

  PubMed
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  In silico design of stable single-domain antibodies with high affinity

  Zhongyao Zhang, Rob van der Kant, Iva Marković, David Vizarraga, Teresa Garcia, Katerina Maragkou, Javier Delgado Blanco, Damiano Cianferoni, Gabriele Orlando, Gabriel Cia, Nick Geukens, Carlo Carolis, Alexander N Volkov, Savvas N Savvides, Maarten Dewilde, Joost Schymkowitz, Luis Serrano Pubul, Frederic Rousseau

  Structure . 2026 Jan 9

  PubMed
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  Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation

  Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Nikolaos Louros

  Nat Commun 2025 Nov 18

  PubMed
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  A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy

  Zhongyao Zhang, Simon D'Hondt, Rob Van der Kant, Guy Hermans, Nick Geukens, Vitor Bernardes Pinheiro, Joost Schymkowitz, Frederic Rousseau, Maarten Dewilde

  Nucleic Acids Res . 2025 Oct 14

  PubMed
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  Toward a thermodynamic taxonomy of amyloid fibrils

  Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau

  Structure 2025 Oct 2

  PubMed