Welcome to the Switch Laboratory

Mapping aggregation-specific interactions in human disease

Our research focuses on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease. In particular, we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions. These latter are especially relevant as they are usually associated with gain of function activities such as neurotoxicity (neurodegeneration).

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Newest publications

  • publication

    CORDAX web server: An online platform for the prediction and 3D visualization of aggregation motifs in protein sequences

    Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz
    Bioinformatics . 2024 Apr 25
    PubMed
  • publication

    Mechanistic insights into the adaptive evolvability of spore heat resistance in Bacillus cereus sensu lato

    Sadhana Khanal, Tom Dongmin Kim, Katrien Begyn, Wouter Duverger, Gertjan Kramer, Stanley Brul, Andreja Rajkovic, Frank Devlieghere, Marc Heyndrickx, Joost Schymkowitz, Frederic Rousseau, Véronique Broussolle, Chris Michiels, Abram Aertsen
    Int J Food Microbiol . 2024 Apr 15
    PubMed
  • publication

    Integrating physics in deep learning algorithms: a force field as a PyTorch module

    Gabriele Orlando, Luis Serrano, Joost Schymkowitz, Frederic Rousseau
    Bioinformatics . 2024 Mar
    PubMed
  • publication

    CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

    CAGI community
    Genome Biol . 2024 Feb
    PubMed
  • publication

    Local structural preferences in shaping tau amyloid polymorphism

    Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D'Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R Mackenzie, Rosa Rademakers, Neil A Ranson, Sheena E Radford, Frederic Rousseau, Joost Schymkowitz
    Nat Commun . 2024 Feb 3
    PubMed
  • publication

    LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

    Baptiste Libé-Philippot, Amélie Lejeune, Keimpe Wierda, Nikolaos Louros, Emir Erkol, Ine Vlaeminck, Sofie Beckers, Vaiva Gaspariunaite, Angéline Bilheu, Katerina Konstantoulea, Hajnalka Nyitrai, Matthias De Vleeschouwer, Kristel M Vennekens, Niels Vidal, Thomas W Bird, Daniela C Soto, Tom Jaspers, Maarten Dewilde, Megan Y Dennis, Frederic Rousseau, Davide Comoletti, Joost Schymkowitz, Tom Theys, Joris de Wit, Pierre Vanderhaeghen
    Cell . 2023 Dec 21
    PubMed